Unravelling the Bi-Functional Electrocatalytic Properties of {Mo72Fe30} Polyoxometalate Nanostructures for Overall Water Splitting Using Scanning Electrochemical Microscope and Electrochemical Gating Methods.

This study reports the use of Keplerate-type {Mo72Fe30} polyoxometalate (POMs) nanostructures as a bi-functional-electrocatalyst for HER and OER in an alkaline medium with a lower overpotential (135 mV for HER and 264 mV for OER), and excellent electrochemical stability. The bi-functional catalytic properties of {Mo72Fe30} POM are studied using a scanning electrochemical microscope (SECM) via current mapping using substrate generation and tip collection mode. Furthermore, the bipolar nature of the {Mo72Fe30} POM nano-electrocatalysts is studied using the electrochemical gating via simultaneous monitoring of the electrochemical (cell) and electrical ({Mo72Fe30} POM) signals. Next, a prototype water electrolyzer fabricated using {Mo72Fe30} POM electrocatalysts showed they can drive 10 mA cm-2 with a low cell voltage of 1.62 V in lab-scale test conditions. Notably, the {Mo72Fe30} POM electrolyzers' performance assessment based on recommended conditions for industrial aspects shows that they require a very low overpotential of 1.89 V to drive 500 mA cm-2, highlighting their promising candidature toward clean-hydrogen production.

GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model through anti-aging effects.

GV1001, which mimics the activity of human telomerase reverse transcriptase, protects neural cells from amyloid beta (Aß) toxicity and other stressors through extra-telomeric function, as noted in our prior in vitro studies. As per a recent phase II clinical trial, it improves cognitive function in patients with moderate to severe dementia. However, the underlying protective mechanisms remain unclear. This study aimed to investigate the effects of GV1001 on neurodegeneration, senescence, and survival in triple transgenic Alzheimer's disease (3xTg-AD) mice. GV1001 (1 mg/kg) was subcutaneously injected into old 3xTg-AD mice thrice a week until the endpoint for sacrifice, and survival was analysed. Magnetic resonance imaging (MRI) and Prussian blue staining (PBS) were performed to evaluate entry of GV1001 entrance into the brain. Diverse molecular studies were performed to investigate the effect of GV1001 on neurodegeneration and cellular senescence in AD model mice, with a particular focus on BACE, amyloid beta1-42 (Aß1-42), phosphorylated tau, volume of dentate gyrus, ß-galactosidase positive cells, telomere length, telomerase activity, and ageing-associated proteins. GV1001 crossed the blood-brain barrier, as confirmed by assessing the status of ferrocenecarboxylic acid-conjugated GV1001 using magnetic resonance imaging and PBS. GV1001 increased the survival of 3xTg-AD mice. It decreased BACE and Aß1-42 levels, neurodegeneration (i.e., reduced CA1, CA3 and dentate gyrus volume, decreased levels of senescence-associated ß-galactosidase positive cells, and increased telomere length and telomerase activity), and levels of ageing-associated proteins. We suggest that GV1001 exerts anti-ageing effects in 3xTg-AD mice by reducing neurodegeneration and senescence, which contributes to improved survival.

Varus-valgus Alignment of Humeral Short Stem in Reverse Total Shoulder Arthroplasty: Does It Really Matter?

BACKGROUND: The utilization of short humeral stems in reverse total shoulder arthroplasty (RTSA) has gained attention in recent times. However, concerns regarding the risk of misalignment during implant insertion are associated with their use. METHODS: Eight fresh-frozen cadaveric shoulders were prepared for dissection and biomechanical testing. A bespoke humeral implant was fabricated to facilitate assessment of neutral, varus, and valgus alignments using a single stem, and 10° was established as the maximum permissible angle for misalignments. Shift in humerus position and changes in deltoid length attributable to misalignments relative to the neutral position were evaluated using a Microscribe 3DLx system. The impingement-free range of motion (IFROM), encompassing abduction, adduction, internal rotation (IR), and external rotation (ER), was gauged using a digital goniometer. The capacity for abduction was evaluated at maximal abduction angles under successive loading on the middle deltoid. A specialized traction system coupled with a force transducer was employed to measure anterior dislocation forces. RESULTS: Relative to the neutral alignment, valgus alignment resulted in a more distal (10.5 ± 2.4 mm) and medial (8.3 ± 2.2 mm) translation of the humeral component, whereas the varus alignment resulted in the humerus shifting more superiorly (11.2 ± 1.3 mm) and laterally (9.9 ± 0.9 mm) at 0° abduction. The valgus alignment exhibited the highest abduction angle than neutral alignment (86.2°, P<0.001). Conversely, the varus alignment demonstrated significantly higher adduction (18.4±7.4°, P<0.001), IR (68.9±15.0°, P=0.014), and ER (45.2±10.5°, P=0.002) at 0° abduction compared to the neutral alignments. Anterior dislocation forces were considerably lower (23.8N) in the varus group compared to the neutral group at 0°ER (P=0.047). Additionally, abduction capability was markedly higher in varus alignment at low deltoid loads than the neutral alignment (5N, P=0.009; 7.5N, P=0.007). CONCLUSIONS: The varus position enhances rotational ROM but increases instability, while the valgus position does not significantly impact ROM or instability compared to the neutral position.

Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial.

BACKGROUND: The TeloVac study indicated GV1001 did not improve the survival of advanced pancreatic ductal adenocarcinoma (PDAC). However, the cytokine examinations suggested that high serum eotaxin levels may predict responses to GV1001. This Phase III trial assessed the efficacy of GV1001 with gemcitabine/capecitabine for eotaxin-high patients with untreated advanced PDAC. METHODS: Patients recruited from 16 hospitals received gemcitabine (1000 mg/m2, D 1, 8, and 15)/capecitabine (830 mg/m2 BID for 21 days) per month either with (GV1001 group) or without (control group) GV1001 (0.56 mg; D 1, 3, and 5, once on week 2-4, 6, then monthly thereafter) at random in a 1:1 ratio. The primary endpoint was overall survival (OS) and secondary end points included time to progression (TTP), objective response rate, and safety. RESULTS: Total 148 patients were randomly assigned to the GV1001 (n = 75) and control groups (n = 73). The GV1001 group showed improved median OS (11.3 vs. 7.5 months, P = 0.021) and TTP (7.3 vs. 4.5 months, P = 0.021) compared to the control group. Grade >3 adverse events were reported in 77.3% and 73.1% in the GV1001 and control groups (P = 0.562), respectively. CONCLUSIONS: GV1001 plus gemcitabine/capecitabine improved OS and TTP compared to gemcitabine/capecitabine alone in eotaxin-high patients with advanced PDAC. CLINICAL TRIAL REGISTRATION: NCT02854072.

GV1001 modulates neuroinflammation and improves memory and behavior through the activation of gonadotropin-releasing hormone receptors in a triple transgenic Alzheimer's disease mouse model.

GV1001 protects neural cells from amyloid-ß (Aß) toxicity and other stressors in in vitro studies and demonstrates clinically beneficial effects in patients with moderate to severe Alzheimer's disease (AD). Here, we investigated the protective effects and mechanism of action of GV1001 in triple transgenic AD (3xTg-AD) mice. We found that GV1001 improved memory and cognition in middle- and old-aged 3xTg-AD mice. Additionally, it reduced Aß oligomer and phospho-tau (Ser202 and Thr205) levels in the brain, and mitigated neuroinflammation by promoting a neuroprotective microglial and astrocyte phenotype while diminishing the neurotoxic ones. In vitro, GV1001 bound to gonadotropin releasing hormone receptors (GnRHRs) with high affinity. Levels of cyclic adenosine monophosphate, a direct downstream effector of activated GnRHRs, increased after GV1001 treatment. Furthermore, inhibition of GnRHRs blocked GV1001-induced effects. Thus, GV1001 might improve cognitive and memory functions of 3xTg-AD mice by suppressing neuroinflammation and reducing Aß oligomers levels and phospho-tau by activating GnRHRs and their downstream signaling pathways.

Chitosan-GSNO nanoparticles: a positive modulator of drought stress tolerance in soybean.

BACKGROUND: Chitosan biopolymer is an emerging non-toxic and biodegradable plant elicitor or bio-stimulant. Chitosan nanoparticles (CSNPs) have been used for the enhancement of plant growth and development. On the other hand, NO is an important signaling molecule that regulates several aspects of plant physiology under normal and stress conditions. Here we report the synthesis, characterization, and use of chitosan-GSNO nanoparticles for improving drought stress tolerance in soybean. RESULTS: The CSGSNONPs released NO gas for a significantly longer period and at a much lower rate as compared to free GSNO indicating that incorporation of GSNO in CSNPs can protect the NO-donor from rapid decomposition and ensure optimal NO release. CS-GSNONPs improved drought tolerance in soybean plants reflected by a significant increase in plant height, biomass, root length, root volume, root surface area, number of root tips, forks, and nodules. Further analyses indicated significantly lower electrolyte leakage, higher proline content, higher catalase, and ascorbate peroxidase activity, and reduction in MDA and H2O2 contents after treatment with 50 µM CS-GSNONPs under drought stress conditions. Quantitative real-time PCR analysis indicated that CS-GSNONPs protected against drought-induced stress by regulating the expression of drought stress-related marker genes such as GmDREB1a, GmP5CS, GmDEFENSIN, and NO-related genes GmGSNOR1 and GmNOX1. CONCLUSIONS: This study highlights the potential of nano-technology-based delivery systems for nitric oxide donors to improve plant growth, and development and protect against stresses.

Retrospective Analysis of the Clinical Characteristics of Patients with Breast Cancer Treated with Telomerase Peptide Immunotherapy Combined with Cytotoxic Chemotherapy.

Purpose: Telomerase activation, a critical step in cancer progression, occurs in approximately 95% of breast cancer cases. Telomerase is an attractive therapeutic target for breast cancer owing to its unique expression pattern. GV1001, a telomerase-derived peptide, is loaded onto human leukocyte antigen (HLA) class II antigen-presenting cells and binds to CD4+ T cell activating immune responses. This study aimed to evaluate the effectiveness and safety of co-administration of GV1001 and cytotoxic chemotherapy in patients with heavily-treated metastatic breast cancer. Patients and methods: We analyzed 63 patients with breast cancer who received both GV1001 and cytotoxic chemotherapy. The GV 1001 administration methods involves 0.56 mg intradermal injection three times during the first week, one time at weeks 2, 3, 4, and 6, and then once every 28 days. The primary endpoint of this study was quality of life according to EORTC QLO-C30 and EQ-5D, while the secondary endpoint was the antitumor response according to RECIST 1.1, progression-free survival, overall survival, and toxicity profile. Results: In 34 patients with HR+ breast cancer evaluable for tumor response, the disease control rate (DCR) and overall response rate (ORR) were 58.8% and 26.4%, respectively. The DCR and ORR were 66.6% and 28.5% in 21 patients with HER-2+ and 50% and 25% in patients with triple-negative breast cancer (TNBC), respectively. The median progression free survival was 10.4, 8.7, and 5.6 months in HR+, HER-2+, TNBC, respectively. The overall survival was 19.7, 13.2, and 9.4 months for patients with HR+, HER-2+, and TNBC, respectively. Most patients had an improved quality of life with statistically significant differences in some variables. The patients in this study experienced no additional toxicities other than the cytotoxic chemotherapy-associated side effects. Conclusion: GV1001 is a relatively safe anticancer vaccine for patients with heavily-treated breast cancer and can to improve the quality of life.

GV1001 Inhibits the Severity of the Ligature-Induced Periodontitis and the Vascular Lipid Deposition Associated with the Periodontitis in Mice.

GV1001, a 16 amino acid peptide derived from the catalytic segment of human telomerase reverse transcriptase, was developed as an anti-cancer vaccine. Subsequently, it was found to exhibit anti-inflammatory and anti-Alzheimer's disease properties. Periodontitis is a risk factor for a variety of systemic diseases, including atherosclerosis, a process in which chronic systemic and vascular inflammation results in the formation of plaques containing lipids, macrophages, foam cells, and tissue debris on the vascular intima. Thus, we investigated the effect of GV1001 on the severity of ligature-induced periodontitis, vascular inflammation, and arterial lipid deposition in mice. GV1001 notably reduced the severity of ligature-induced periodontitis by inhibiting gingival and systemic inflammation, alveolar bone loss, and vascular inflammation in wild-type mice. It also significantly lowered the amount of lipid deposition in the arterial wall in ApoE-deficient mice receiving ligature placement without changing the serum lipid profile. In vitro, we found that GV1001 inhibited the Receptor Activator of NF-κB ligand (RANKL)-induced osteoclast formation and tumor necrosis factor-α (TNF-α)-induced phenotypic changes in endothelial cells. In conclusion, our study suggests that GV1001 prevents the exacerbation of periodontitis and atherosclerosis associated with periodontitis partly by inhibiting local, systemic, and vascular inflammation and phenotypic changes of vascular endothelial cells.

Topochemically prepared tungsten disulfide nanostructures as a novel pseudocapacitive electrode for high performance supercapacitor.

The topochemical preparation of nanostructured materials (NMs) has received significant attention in recent years due to the exceptional electrochemical properties exhibited by the resulting NMs. This work focuses on the preparation of two-dimensional tungsten di-sulfide (WS2) nanostructures through the topochemical conversion of tungsten trioxide (WO3) nanostructures and also evaluates their potential applications as electrode materials for supercapacitors (SCs). The X-ray diffraction and photoelectron studies conducted in this research reveal the conversion of hexagonal WO3 into hexagonal WS2 nanosheets, accompanied by changes in oxidation states. The FE-SEM and HR-TEM studies confirm the formation of WS2 in the sheet-like morphologies with lateral dimensions of 100 × 100 nm. The electrochemical investigation, using techniques such as CV, galvanostatic CD, and EIS, confirmed the presence of intercalation pseudocapacitance in the WS2 electrode, with a higher electrode-specific-capacitance (260 F g-1) than that of WO3 electrode. The WS2 symmetric SC delivered high device capacitance (59.17 F g-1), energy density (8.21 Wh kg-1) and power density (3,750 W kg-1) with better cyclic stability over 5000 cycles. These experimental findings show that the topochemically synthesized WS2as novel supercapacitor electrodes might be useful for the advancement of future-generation energy storage devices.

Untethered Magnetic Soft Robot with Ultra-Flexible Wirelessly Rechargeable Micro-Supercapacitor as an Onboard Power Source.

Soft robotics has developed rapidly in recent years as an emergent research topic, offering new avenues for various industrial and biomedical settings. Despite these advancements, its applicability is limited to locomotion and actuation due to the lack of an adequate charge storage system that can support the robot's sensory system in challenging conditions. Herein, an ultra-flexible, lightweight (≈50 milligrams), and wirelessly rechargeable micro-supercapacitor as an onboard power source for miniaturized soft robots, capable of powering a range of sensory is proposed. The simple and scalable direct laser combustion technique is utilized to fabricate the robust graphene-like carbon micro-supercapacitor (GLC-MSC) electrode. The GLC-MSC demonstrates superior areal capacitance (8.76 mF cm-2 ), and maintains its original capacitance even under extreme actuation frequency (1-30 Hz). As proof of conceptthe authors fabricate a fully integrated magnetic-soft robot that shows outstanding locomotion aptitude and charged wirelessly (up to 2.4 V within 25s), making it an ideal onboard power source for soft robotics.

Effects of GV1001 on Language Dysfunction in Patients With Moderate-to-Severe Alzheimer's Disease: Post Hoc Analysis of Severe Impairment Battery Subscales.

Background and Purpose: The efficacy and safety of GV1001 have been demonstrated in patients with moderate-to-severe Alzheimer's disease (AD). In this study, we aimed to further demonstrate the effectiveness of GV1001 using subscales of the Severe Impairment Battery (SIB), which is a validated measure to assess cognitive function in patients with moderate-to-severe AD. Methods: We performed a post hoc analysis of data from a 6 month, multicenter, phase 2, randomized, double-blind, placebo-controlled trial with GV1001 (ClinicalTrials.gov, NCT03184467). Patients were randomized to receive either GV1001 or a placebo for 24 weeks. In the current study, nine subscales of SIB-social interaction, memory, orientation, language, attention, praxis, visuospatial ability, construction, and orientation to name- were compared between the treatment (GV1001 1.12 mg) and placebo groups at weeks 12 and 24. The safety endpoints for these patients were also determined based on adverse events. Results: In addition to the considerable beneficial effect of GV1001 on the SIB total score, GV1001 1.12 mg showed the most significant effect on language function at 24 weeks compared to placebo in both the full analysis set (FAS) and per-protocol set (PPS) (p=0.017 and p=0.011, respectively). The rate of adverse events did not differ significantly between the 2 groups. Conclusions: Patients with moderate-to-severe AD receiving GV1001 had greater language benefits than those receiving placebo, as measured using the SIB language subscale.

Recent Advances in Triboelectric Nanogenerators: From Technological Progress to Commercial Applications.

Serious climate changes and energy-related environmental problems are currently critical issues in the world. In order to reduce carbon emissions and save our environment, renewable energy harvesting technologies will serve as a key solution in the near future. Among them, triboelectric nanogenerators (TENGs), which is one of the most promising mechanical energy harvesters by means of contact electrification phenomenon, are explosively developing due to abundant wasting mechanical energy sources and a number of superior advantages in a wide availability and selection of materials, relatively simple device configurations, and low-cost processing. Significant experimental and theoretical efforts have been achieved toward understanding fundamental behaviors and a wide range of demonstrations since its report in 2012. As a result, considerable technological advancement has been exhibited and it advances the timeline of achievement in the proposed roadmap. Now, the technology has reached the stage of prototype development with verification of performance beyond the lab scale environment toward its commercialization. In this review, distinguished authors in the world worked together to summarize the state of the art in theory, materials, devices, systems, circuits, and applications in TENG fields. The great research achievements of researchers in this field around the world over the past decade are expected to play a major role in coming to fruition of unexpectedly accelerated technological advances over the next decade.

Decoupling Contact and Rotary Triboelectrification vs Materials Property: Toward Understanding the Origin of Direct-Current Generation in TENG.

Direct-current (DC) triboelectric nanogenerators (TENGs) are increasingly recognized as next-generation power sources for widespread applications. Research has recently focused on developing novel materials as active layers for DC TENGs and device configurations to elucidate the working mechanisms. In this work, we report the use of a carbyne (dehydrohalogenated poly(vinylidene fluoride) (PVDF)) film as a positive-type friction layer for DC TENGs for efficient harvesting of rotary energy. The fabricated carbyne-based rotary TENG generates an output voltage (120 V) with excellent mechanical stability and peak power density (500 µW m-2). The mechanism of DC output generation from the carbyne-based rotary TENG is explained based on halogen removal from PVDF and the electrostatic breakdown effect. Additionally, the humidity effects on the fabricated carbyne-based rotary TENG toward a self-powered humidity sensor are studied in detail with the aid of in situ Raman analysis, Fourier transform infrared spectroscopy, and open-circuit potential measurements. Together, our experimental results demonstrate that using carbyne as an active triboelectric layer for DC TENGs would greatly benefit the next generation of power devices.

Effective regeneration of mixed composition of spent lithium-ion batteries electrodes towards building supercapacitor.

Recycling of different manufacturers of spent lithium-ion batteries cathode and anode via a simple regeneration process has an opportunity to fabricate new energy devices. In this study, the different manufacturers of spent LIB cathode pieces were subjected to lixiviation process and found the best-optimized conditions such as tartaric acid concentration (2.5 M), H2O2 concentration (7.5 vol%), solid-liquid ratio (80 g/L), temperature (80 °C), and lixiviation time (80 min) for maximum ~ 99% extraction efficiency of metals. Further, 3D-MnCo2O4 (MCO) spheres were regenerated from the cathode lixivium containing metal ions via hydrothermal technique. Besides, anode graphite and Al foils after cathode lixiviation were exploited to prepare reduced graphene oxide (RGO) at room temperature in a simple method. The electrochemical performance of both regenerated electrodes from spent LIBs was explored in the half-cell configuration using the 1 M Na2SO4 electrolyte. Additionally, the constructed MCO//RGO asymmetric supercapacitor device offers an operational voltage of 1.8 V and displays a high energy density of ~ 23.9 Wh kg-1 at 450 W kg-1 with 8000 cycles. This alternative recycling method proposes the possibility to construct high-energy storage devices from different compositions of spent LIBs.

Two Faces Under a Hood: Unravelling the Energy Harnessing and Storage Properties of 1T-MoS2 Quantum Sheets for Next-Generation Stand-Alone Energy Systems.

The two-dimensional 1T-MoS2 quantum sheets (QSs) continuously seek attention due to their extraordinary energy harnessing and storage properties towards designing an all-in-one self-charging power system (SCPS). Herein, we have utilized the superior dual-functional nature of exfoliated MoS2 QSs for SCPS via fabricating all-solid-state microsupercapacitors (MSC) as an energy storage device and triboelectric nanogenerator (TENG) with MoS2 QSs based charge-trapping interfacial layer as the energy harvester. The electrochemical analysis of MoS2 QSs MSC indicated their superior capacitive properties with a high areal capacitance (4.3 mF cm-2), energy density (0.38 µWh cm-2), and long cycle life. Furthermore, we emphasize the fabrication of MSC with shape diversity and performance uniformity via construction in several designable shapes, which exhibit superior electrochemical performances. The MoS2 QSs based charge-trapping layer enhances the output performance of TENG dramatically with a peak power density as large as 10 µW cm-2, which is 13-fold greater than that of the pristine TENG. As proof of the concept, we fabricated an all MoS2 based SCPS which showed their ability to self-charge up to a maximum of 1050 mV, outperforming many SCPS reported previously. Overall, this work creates a way to utilize the bifunctional properties of MoS2 QSs for the development of next-generation SCPS.

Ferroelectric-semiconductor BaTiO3-Ag2O nanohybrid as an efficient piezo-photocatalytic material.

Piezo-photocatalysis is a new concept of utilizing nanohybrids comprising piezoelectric and photocatalytic materials for enhancement in advanced oxidation process under the presence of light and mechanical energy. In this study, we explored the effectiveness of piezo-photocatalysis via examining their catalytic activity towards the degradation of azo dye (Rhodamine-B) and standard pollutant (Phenol) catalyzed by ferroelectric-semiconductor (BaTiO3-Ag2O) nanohybrids. Further, the enhancement in piezo-photocatalysis has been achieved via persulfate activation and the role of free radicals was examined by quenchers. A plausible mechanism for the improved piezo-photocatalysis of BaTiO3-Ag2O nanohybrid using persulfate activation has been discussed in detail. The removal mechanism of Rhodamine-B has been investigated using analytical techniques such as HPLC and EPR. Our experimental study demonstrated that the combination of piezo-photocatalysis with persulfate activation will provide higher reaction rate which will be beneficial towards the degradation of complex molecular pollutants derived from industrial sectors.

LiTaO3-Based Flexible Piezoelectric Nanogenerators for Mechanical Energy Harvesting.

Mechanical energy is one of the freely available green energy sources that could be harvested to meet the small-scale energy demand. Piezoelectric nanogenerators can be used to harvest the biomechanical energy that is available in everyday human life and power various portable electronics. Herein, a ferroelectric material, i.e., lithium tantalate (LiTaO3), was synthesized and used to fabricate a flexible piezoelectric nanogenerator (FPNG). Generally, ferroelectric materials display a strong electrostatic dipole moment and high piezoelectric coefficient, thus resulting in enhanced electrical performance. First, LiTaO3 nanoparticles were synthesized and loaded into poly(vinylidene difluoride) (PVDF) to form a piezoelectric film and then, the piezoelectric composite film was sandwiched between two aluminum electrodes to fabricate an FPNG. The effect of the electrical performance of FPNG as a function of the concentration of LiTaO3 loaded into PVDF was systematically investigated and optimized. The 2.5 wt % FPNG exhibited open-circuit voltage, short-circuit current, and power density values of ∼18 V, ∼1.2 µA, and ∼25 mW/m2, respectively. Furthermore, the FPNG revealed good electrical stability and mechanical durability. Finally, the FPNG was employed as a weight sensor to harvest various biomechanical energies and operate low-power- electronics.

Electrospun Polymer-Derived Carbyne Supercapacitor for Alternating Current Line Filtering.

The filtering device is a vital component of electronic goods that rectifies ripples which occur upon converting alternating current (AC) to direct current (DC) and attenuates high-frequency noise during switching or voltage declines. Classical filtering devices suffer from low performance metrics and are bulky, limiting their use in modern electronic devices. The fabrication process of electrode materials for high-frequency symmetric supercapacitor (HFSSC) is complicated, hindering commercialization. Herein, for the first time, the design of a high-performance stand-alone carbyne film comprised of sp/sp2 -hybridized carbon as an electrode for AC filtering under a wide frequency range is reported. The carbyne film as HFSSC shows the ideal capacitive behavior at ultrahigh scan rate of 10 000 V s-1 with excellent linearity which is top among the reported AC line filter capacitor. The carbyne HFSSC exhibits a high energy density of 703.25 µF V2  cm-2 at 120 Hz, which is superior to that of current commercial electrolytic filters and many reported AC line supercapacitors. As a proof of concept, a carbyne device is implemented in a real time AC to DC adaptor that demonstrates excellent filtering performance at high frequencies.

Metal-Amino Acid Nanofibers based Triboelectric Nanogenerator for Self-Powered Thioacetamide Sensor.

The biomolecules offer different metal-binding sites to form a coordination polymer with structural diversity. The coordination directed one-dimensional metal-biomolecule nanofibers (Cu-Asp NFs) designed using copper as metal ion and aspartate as a ligand for triboelectric nanogenerator (TENG) is reported here. The different characterization techniques reveal the detailed characteristics of the synthesized Cu-Asp NFs. The robust coating of the Cu-Asp NFs is achieved using a simple tape cast coater. The bending and water dipping studies suggest the stability of the coated material. The relative polarity test and Kelvin probe force microscopy (KPFM) reveal the position of Cu-Asp in the triboelectric series. The Cu-Asp NFs and Teflon are used as the active material for the fabrication of freestanding mode (NF-TENG) and contact-separation mode (cNF-TENG) TENG. The NF-TENG generates an output of 200 V and 6 µA. The simple ion deposition technique enhances the voltage, current, and transferred charge of cNF-TENG by 2.5, 8, and 3 times. The use of the material for the single electrode sliding mode device further confirms the coated material's stability and robustness. A selective self-powered thioacetamide sensor is developed with the cNF-TENG, which exhibits a sensitivity of 0.76 v mM-1. Finally, NF-TENG is demonstrated for powering up numerous portable electronics.